By Jenny Menzel, H.C.
According to the 2020 Cannabidiol (CBD): Global Markets report, the hemp-derived CBD oil industry is expected to grow from $500 million to nearly $3 billion by 2025. Not surprising considering the mounting evidence of CBD’s ability to naturally alleviate pain, regulate sleep, and more.
A 2018 review published in Molecules reiterated that cannabinoids’ lipophilic nature — that is, the ease in which CBD dissolves in lipid fats — is what makes CBD oil a favored delivery method among consumers and manufacturers alike. However, even with CBD’s success in clinical trials, oral bioavailability was shown to be quite low, making it a suitable candidate for being nanosized — a process that breaks CBD down into millions of tiny particles that can more easily be assimilated by the body.
Is this next generation of CBD bioavailability superior in achieving even more therapeutic effects? Let’s look at the details of the technology to understand more.
What is Nanotechnology?
Nano, a prefix meaning "one billionth," is used to measure units in research fields that enlist nanotechnology to build materials on a microscopic scale. Many different fields of science use nanotechnology, but in the realm of medicine, nanotechnology essentially takes medicinal materials and "nano-sizes" them — dividing the components into millions of microparticles. Often referred to as nanomedicine, this process enhances these materials' therapeutic value by increasing potency and promoting a greater chemical reactivity within the body than their larger counterparts could.
In other words, nanotechnology can turn one drop of CBD oil into millions. These microparticles are so small that they may measure just a fraction of the width of one strand of hair — millions of them being able to rest on the surface of a small nail head. This emulsification allows CBD to be readily available for fast absorption, bypassing much of the digestive process.
How Water-Soluble CBD Works
Our bodies are made up of approximately 60% water, making us more water-compatible than oil-compatible. Inversely, as discussed earlier, CBD is most easily dissolved in fats and oils — a compound known to mix poorly with water. However, when large CBD particles are emulsified with nanotechnology, nanosized CBD oil eagerly and effectively mixes with water, thereby enhancing the absorption rate dramatically. A significant increase in bioavailability results, amplifying CBD's therapeutic benefits ten-fold.
Questions to Ask When Shopping For Nano CBD
There are still many myths and conflicting sources of information as the CBD trail continues to be forged. Knowing what to look for in a CBD product is important, as well as understanding general industry lingo. Consider the following when shopping for nanosized CBD:
- Has your product been tested for label accuracy by an ISO-compliant lab?
- Does your product have a Certificate of Analysis (COA)?
- Is it free of toxic contaminants?
- Do you need full-spectrum, broad-spectrum, or isolate?
- Did you check for any applicable state laws?
- Does your supplier have an excellent reputation and good reviews?
Even when finding an excellent nanosized CBD product, there are details and contradictions to be aware of to ensure product shelf life and general safety.
- Before use, water-soluble CBD needs to be shaken well and refrigerated after opening.
- If under 18, the supervision of an adult is recommended while using nanosized CBD.
- If you are pregnant or nursing, are on any medications, or if you have experienced any side effects from CBD in the past, do not use water-soluble CBD until you’ve consulted with your primary care provider.
On the heels of the medicinal marijuana bullet train, the CBD industry is just getting started. With continued growth and inevitable transformation projected for the future, suppliers seek ways to set themselves apart from the increasingly saturated competition.
Nanotechnology is successfully being utilized by the CBD industry to do just that. By nanosizing CBD and increasing its bioavailability through the process of emulsification, users of water-soluble CBD may experience up to 10 times more therapeutic benefit when compared to regular CBD oil — an option certainly worth looking into.
- Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018;23(10):2478. Published 2018 Sep 27. doi:10.3390/molecules23102478
- Cannabidiol (CBD) Oil: Global Markets. Research and Markets website. https://www.researchandmarkets.com/reports/5143008/cannabidiol-cbd-oil-global-markets?utm_source=GNOM
- The Water in You: Water and the Human Body. USGS website. https://www.usgs.gov/special-topic/water-science-school/science/water-you-water-and-human-body?qt-science_center_objects=0
- What is Nanotechnology? Nano.gov website. https://www.nano.gov/nanotech-101/what/definition